How Aeknil works
AEKNIL (Paracetamol) is a drug with
antipyretic (fever-reducing) and analgesic (pain-relieving)
properties. It has a weak anti-inflammatory action as well.
Paracetamol reduces fever by inhibiting the formation and
release of prostaglandins in the central nervous system and
inhibiting the action of endogenous pyrogens at the hypothalamic
The mechanism of analgesic action of Paracetamol is not fully
established. Paracetamol may produce analgesia by inhibiting
prostaglandin synthesis centrally and elevating the pain
Benefits of Aeknil
AEKNIL has been in the market since 1961 and has established
itself as a brand of choice and trust among healthcare
professionals all over the world. Over the years, AEKNIL has
evolved from a single dosage form into multiple product
extensions like infusions, tablets, pediatric drops, and syrups
to cater to all age groups. All products are manufactured as per
cGMP guidelines and have a well-documented safety and efficacy
Numerous clinical trials and pharmacokinetic studies have been
performed on AEKNIL range of products over a span of 40 years at
multiple sites in India, Middle-East, South-East Asia and
These trials have confirmed the quality, safety, and efficacy
profile of AEKNIL products and have made it a brand of choice and
trust among the medical fraternity in India and around the
A brief, non-exhaustive list of clinical studies with AEKNIL
range of products is given below.
- Effect of parenteral acetaminophen on the attenuation of post-operative pain subsequent colectomy. A randomized, double-blind, clinical trial. Dr.Issabeagloo et al, Department of Pharmacology, Islamic Azad University, Tabriz, Iran. Life Science Journal 2013;10(4s)
- Analgesic efficacy of AEKNIL (Paracetamol) injection in immediate post-episiotomy/perineal tear pain management. Dr.I.A.Sotande et al, Oba Ademola Maternity Centre, Nigeria. OAMCJ 2007.
- Use of n-acetylparaaminophenol (Paracetamol) in parenteral form in pediatrics. Dr.Versha Modi, Department of Pediatrics, B.J.Medical College and Civil Hospital, Ahmedabad, Gujarat. Pediatric Clinics of India, July 1974.
- Therapy of fever with special reference to Paracetamol: A clinical trial. Dr.Manoranjan Sahai, Department of Pediatrics, Darbhanga Medical College, Laheria Sarai, Bihar. DMCJ 1972.
- Clinical trials with AEKNIL brand of Paracetamol. Dr.Lohe, Deshpande et al, G.T. Hospital, Bombay. The Bombay Hospital Journal. Vol. 9, No. 3, July 1967.
- A Pharmacokinetic study of AEKNIL (Paracetamol) Injection. Dr.Esperanza Icasas-Cabral, Philippine Heart Center, Manila,
Philippines. PHCJ 1998.