How Aeknil works

AEKNIL (Paracetamol) is a drug with antipyretic (fever-reducing) and analgesic (pain-relieving) properties. It has a weak anti-inflammatory action as well.

Paracetamol reduces fever by inhibiting the formation and release of prostaglandins in the central nervous system and inhibiting the action of endogenous pyrogens at the hypothalamic thermoregulatory centers.

The mechanism of analgesic action of Paracetamol is not fully established. Paracetamol may produce analgesia by inhibiting prostaglandin synthesis centrally and elevating the pain threshold.

Benefits of Aeknil

AEKNIL has been in the market since 1961 and has established itself as a brand of choice and trust among healthcare professionals all over the world. Over the years, AEKNIL has evolved from a single dosage form into multiple product extensions like infusions, tablets, pediatric drops, and syrups to cater to all age groups. All products are manufactured as per cGMP guidelines and have a well-documented safety and efficacy profile.

Clinical Studies

Numerous clinical trials and pharmacokinetic studies have been performed on AEKNIL range of products over a span of 40 years at multiple sites in India, Middle-East, South-East Asia and Africa.

These trials have confirmed the quality, safety, and efficacy profile of AEKNIL products and have made it a brand of choice and trust among the medical fraternity in India and around the world.

A brief, non-exhaustive list of clinical studies with AEKNIL range of products is given below.

Clinical trials

• Effect of parenteral acetaminophen on the attenuation of post-operative pain subsequent colectomy. A randomized, double-blind, clinical trial. Dr.Issabeagloo et al, Department of Pharmacology, Islamic Azad University, Tabriz, Iran. Life Science Journal 2013;10(4s)
• Analgesic efficacy of AEKNIL (Paracetamol) injection in immediate post-episiotomy/perineal tear pain management. Dr.I.A.Sotande et al, Oba Ademola Maternity Centre, Nigeria. OAMCJ 2007.
• Use of n-acetylparaaminophenol (Paracetamol) in parenteral form in pediatrics. Dr.Versha Modi, Department of Pediatrics, B.J.Medical College and Civil Hospital, Ahmedabad, Gujarat. Pediatric Clinics of India, July 1974.
• Therapy of fever with special reference to Paracetamol: A clinical trial. Dr.Manoranjan Sahai, Department of Pediatrics, Darbhanga Medical College, Laheria Sarai, Bihar. DMCJ 1972.
• Clinical trials with AEKNIL brand of Paracetamol. Dr.Lohe, Deshpande et al, G.T. Hospital, Bombay. The Bombay Hospital Journal. Vol. 9, No. 3, July 1967.

Pharmacokinetic Studies

1. A Pharmacokinetic study of AEKNIL (Paracetamol) Injection. Dr.Esperanza Icasas-Cabral, Philippine Heart Center, Manila, Philippines. PHCJ 1998.